The most common form of commercial T-shirt decoration is screen-printing. In screen-printing, a design is separated into individual colors. Plastisol or water based inks are applied to the shirt through mesh screens which limits the areas where ink is deposited. In most commercial T-shirt printing, the specific colors in the design are used.

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To achieve a wider color spectrum with a limited number of colors, process printing or simulated process is effective. Process printing is best suited for light colored shirts. Simulated process is best suited for dark colored shirts.